Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells
Cell Physiol Biochem 57:2441 Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
The results convincingly demonstrate that protein aggregation induces senescence of many cell types in the brain, and that senolytics effectively reduce pathogenesis (3537)
FDA reviewers have also cautioned that a peptide's similarity to a naturally occurring substance does not eliminate potential risks
Reduced GSH levels shown by decreases in this ratioboth in the plasma and intracellularlyreflect intracellular shifts in oxidative burden and are indicative of immune dysfunction and progression of various disease states such as infection, sepsis, and age-related immune system decline (Morris et al., 2012