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Oral glutathione supplements are digested and absorbed in the gastrointestinal tract, which results in slower and more gradual increases in circulating glutathione levels than injections
It is now apparent that the production of primary immune mediators, which include cytokines and chemokines, is dependent on the recruitment of inflammatory cells, particularly innate immune cells such as neutrophils, macrophages, and DCs
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In addition, local hypoxic, acidic, and low-glucose environments further augment energy metabolism reprogramming in tumor cells, which not only upregulates antiapoptotic proteins, including protein kinase B (Akt) and hexokinase 2 (HK2) but also inhibits the proliferation of T lymphocytes, facilitating tumor cell immune escape [198]
