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5 Conclusion Therefore, the mitochondrial dysfunction observed in aging is accompanied by the intracellular GSH/GSSG imbalance, a decrease of the H 2 S content in organelles and the expression levels of UCP3 , as well as the uncoupling of mtNOS with an increase in ROS production, disruption of Ca 2+ homeostasis, etc., which leads to the induction of mPTP with high conductance and causing cardiac dysfunction

Leppilahti M, Tammela TL, Huhtala H et al: Prevalence of symptoms related to interstitial cystitis in women: A population based study in finland

References Food and Nutrition Board, Institute of Medicine

Astaxanthin also attenuates the increase in CHOP and ER chaperone protein via the MAPK pathway and inhibits the influx of calcium ions (Zhang et al., 2018