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The dose was increased weekly by another 21mg patch unless participants reported adverse effects or did not wish to increase the dose, up to a maximum of four patches totalling 84mg/day

[77] Recurrence, death, and SNL response In September 1988, after tests showed no signs of cancer, Radner went on a maintenance chemotherapy treatment to prolong her remission, but three months later, in December, she learned that the cancer had returned