Aamann L, Deshpande N, Dam G, et al
As research continues to advance, the combination of ferroptosis with existing therapies, such as chemotherapy, immunotherapy and targeted treatments, holds great potential for improving the prognosis and survival rates of PDAC patients
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564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice
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