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42 Another RCT studied cyano-B12, 1500 g three times per day for 2 weeks (route not reported), in patients with seasonal affective disorder and found no improvements in either the B12 or the placebo group

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The SURMOUNT-2 trial focused specifically on participants with type 2 diabetes, showing average reductions of 12.8% at 10mg and 14.7% at 15mg