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GLUT4 upregulation depends on stable NAD+ levels, further supporting the core mechanism of nicotinamide metabolism and NAD+ elevation

investigated the renal effects of a 3-day rhIGF-1 treatment (100 g/kg twice daily) in 4 adult patients with advanced CKD (GFR 2155 ml/min/1.73 m 2 ) showing significant increases of both GFR and RPF in all patients, which was associated with a small increase in kidney size [176]

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