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This offers a direct reference for prostate cancer (PCa): in patients resistant to AR pathway inhibitors (e.g., abiraterone, enzalutamide), the LPA axis may serve as an analogous escape pathway. By activating non-classical AR signaling, LPA (unspecified species) drives castration-resistant PCa (CRPC)

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There is lack of evidence on the proper use of melatonin according to the individual rhythms