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In some embodiments, the controlled-release auris-acceptable microspheres are combined in a controlled-release auris-acceptable increased-viscosity formulation or composition

Gut 55 , 415424 (2006)

The membranes were prehybridized at 60C for 2 hours, then hybridized at 60C for 10 hours, and washed with wash solution twice for 15 minutes

While short-term preclinical studies suggest favorable safety, chronic administration effects on angiogenesis, growth factor signaling, and tissue remodeling over years of use remain unknown