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Statements Author contributions MS: Software, Writing original draft

Intracerebroventricular and intravenous administration of synthetic DSIP in rabbits and rats has been reported to increase the proportion of EEG delta activity and slow-wave sleep without consistently suppressing REM (paradoxical) sleep (Schoenenberger & Monnier, 1977

In this review, we proposed that there are two main insults that precipitate hyperoxia-induced AKI: (1) dysfunction due to reduced renal blood flow and alteration of the lung-heart-kidney axis, and (2) cellular harm due to inflammation and oxidative stress

Whilst some patients would prefer injections to skin patches or nasal sprays to sub-lingual tablets or sprays others might, and this already happens in a few cases, they might prefer daily oral tablets