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Furthermore, intracellular Fe 2+ is pumped into the extracellular space through membrane ferritin 1 (SLC40A1/FPN1) to strictly maintain cellular iron homeostasis ( Many studies have demonstrated that iron metabolism-related proteins could be used as targets to regulate ferroptosis

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8,18,19,20,21,22,23,24,25,26,27 Pathology of neuroglia is complex, disorder- and context-specific, and includes various forms of reactivity, atrophy, loss and gain of function