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Some diseases that affect the end of the small intestine where vitamin B12 is absorbed may affect the absorption of the vitamin - for example, Crohn's disease

Similarly, anyone experiencing unexplained fatigue, weakness, neurological symptoms (such as numbness, tingling or problems with balance), or difficulty losing weight despite appropriate lifestyle measures should consult their GP

But continuously altering systemic methylation every day for a year straight is a very different proposition, and its precisely the scenario with zero human data behind it

Thats a short list, deliberately

If supplements are the cause, reducing or stopping supplementation is the only step needed