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doi: 10.3382/ps.2008-00392 20 BrqueC.SuraiP.BrillardJ

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Activation of macrophages by microbial products such as LPS, Th1 cytokines such as IL-1, IFN-, or TNF-, or stress such as hypoxia recruits macrophages to the M1 pathway and induces the expression of the iNOS gene, also known as macNOS because it was first discovered in activated macrophages (Molecular and epigenetic basis of, 2015)

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The result is a more stable molecule with a longer functional duration in the bloodstream and a more sustained pituitary signal