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If Phase 2 capacity is insufficient relative to Phase 1 activity, toxin clearance is impaired and symptom burden may increase rather than resolve

Moreover, another critical challenge for clinical translation is the lack of standardized biomarkers to reliably monitor ferroptosis inhibition in patients

BCAT1 expressed in the cytoplasm was highly expressed in human epidermal growth factor receptor 2 positive (HER2 + ) breast cancer, while BCAT2 expressed in the mitochondria tended to be highly expressed in estrogen receptor-positive (ER + ) breast cancer

L-glutamine supplements are typically available in powder or capsule forms

In contrast, mice in the LC group also lacked luster but demonstrated improved food intake and gained weight compared to the EAM mice (Figure 2A)