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The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models

Studies have shown that it can resist the toxicity of APAP to hepatocytes by activating Nrf2

This window accounts for tissue depot retention beyond serum clearance (which occurs within 30 hours based on the peptides 46 hour half-life) and individual metabolic variation

10.1097/01.blo.0000144971.12731.a2 62 FengX.McDonaldJ

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