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Polyvinyl chloride (PVC) plastic fragments release Pb additives that are bioavailable in zebrafish

Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

Treatment with FOS and GOS also reduced TNF-, COX-2, Caspase-3, Iba-1, and GFAP-positive cells in the dentate gyrus, decreasing neuroinflammation and neuronal death caused by chronic HFD consumption

Masako S, Akiko H, Toshiko M, Mayu H, Yutaka M, Mizutani S et al

The first group reduces the bioavailability of nitric oxide (NO), an important molecule for the relaxation of the blood vessels