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A common combination protocol: Epitalon: 10-day injection cycle (1 to 2 mg daily) every 4 to 6 months Pinealon: Daily sublingual or injection between Epitalon cycles DSIP: Added as needed for acute sleep difficulties or during high-stress periods The stacking approach allows each peptide to address a different aspect of sleep dysfunction

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An animal study revealed that when DSIP was directly injected into the bulbo-mesencephalo-thalamic recruitment system, it induced slow-wave sleep and Naloxone-reversed sleep spindle activity

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