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5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT), a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide

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Hepatology 68 , 1574 (2018)

Cu's presence in SOD supports antioxidant activity, safeguarding retinal cells from oxidative damage, which is particularly relevant in preventing conditions like AMD

While it makes achieving sustained systemic levels difficult, its perfectly suited for triggering rapid signaling cascades or for localized topical use