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To strike a balance between effectiveness and the risk of reducing stress, physicians should use a cautious, step-by-step approach, giving priority to dietary and lifestyle changes first, then closely monitoring antioxidant supplementation

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( Reference Lawler, Barnes and Wu 34 ) demonstrated a direct doseresponse relationship of creatine concentration with superoxide anion (O 2 ), peroxynitrite (OONO ) and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) as determined by the rate of renewal of the ABTS + radical, and concluded that creatine has a significant role as an antioxidant