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The VPA_RAT group exhibited lower species richness than the Control group, evidenced by reduced values in Chao1 (Figure S3A), Faith PD (Figure S3B), and observed features indices (Figure S3C)

In addition, nicotinamide, the primary NNMT substrate 95,96 , is broken down by Lactobacillus arabinosis into nicotinic acid and ammonia 56

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