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The loss of enterohepatic recirculation would definitely cause an additional loss of 5mcg of B12 that is not recovered from bile

Two things to check first

By inhibiting NNMT, the compound preserves these critical cofactors, restoring sirtuin activity and normal energy expenditure in adipocytes

In cases of diagnostic uncertainty, additional tests such as holotranscobalamin or methylmalonic acid may be considered

AOD-9604 also appears in cartilage repair research (originally investigated for osteoarthritis before pivoting to obesity), because the hGH fragment retains some regenerative signaling without the proliferative risks of full hGH