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May 2012;187(5):1645-1649

In the future, it may be necessary to develop cascade response systems that can respond to multiple microenvironmental signals (such as pH, ROS, and specific enzymes) to achieve more precise control of drug release

For diabetics, fasting improves insulin sensitivity via liver glycogen regulation, per ADA guidelines

these HGF mimics have utility as AngIV-related pharmaceuticals and can function as therapeutic agents in disorders where inhibition of the HGF/Met system would be clinically advantageous