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It is a cofactor for lysyl oxidase, the enzyme that crosslinks new collagen and elastin into mature, stable matrix proteins

Alcohol and its metabolite acetaldehyde exert a direct toxic effect to the intestinal tight junctions with a redistribution of ZO-1 and occludin (152, 153)

Mechanistic studies to better understand the molecular targets and pathways involved in peptide action could help identify potential adverse effects and inform safer clinical use

The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults

While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)