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The first step in creatine synthesis involves the reversible transfer of the amidino group of arginine to glycine to form guanidinoacetic acid (GAA) and ornithine in a reaction catalysed by the enzyme l-arginine:glycine amidinotransferase in the kidneys

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In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin

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