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It has been shown to function as an inducer of metastatic genes in breast cancer, including CXCR4 and MMP1 [218]

AMPK enzyme activates, inhibiting mTOR (growth pathway) to favor cleanup

Although low levels of plasma UA may detrimentally affect cognitive function, 27 patients with HU or gout might have a decreased risk of neurodegenerative diseases (such as Alzheimers disease and dementia) and an increased risk of cerebrovascular disease

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Furthermore, this review provides a comprehensive summary of specific antiangiogenic drugs, and relevant studies assessing the reversal of drug resistance in breast cancer