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Similarly, in vitro studies demonstrated that GLP-1RA reduced IL-1 production by pro-inflammatory M1 macrophages and increase of IL-10 production by anti-inflammatory M2 macrophages [95]

Results from experimental studies have suggested that pharmacological doses of citicoline (CDP-choline) could enhance the metabolism of glucose and the biosynthesis of phospholipids and neurotransmitters, while limiting the degradation of phospholipids in neuronal membranes in models of ischemia and neurodegenerative diseases (reviewed in 92)

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