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If GI symptoms are still significant, the documented approach is to hold the current dose longer rather than escalate on schedule

One method for determining sufficient mucoadhesiveness includes monitoring changes in the interaction of the composition with a mucosal layer, including but not limited to measuring changes in residence or retention time of the composition in the absence and presence of the excipient

21shows a table showing semi-quantitative analysis of hair cell protection in cochlear explants pretreated for 1.5 hours and then co-treated with the specified compounds of interest at the listed concentrations and 10 M cisplatin for up to 72 hours

Ensure sourcing from reputable laboratories with verified purity

Bock-Marquette 2004