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Common signs of possible vitamin B12 deficiency can include fatigue or weakness, brain fog or memory issues, shortness of breath, pale or jaundiced skin, and tingling or numbness in the hands and feet

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The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

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