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Cells have their DNA repair mechanism, and DNA adducts can interfere with their ability to correct DNA damage

Phase I consist primarily of microsomal enzymes, which are found abundantly in the liver, gastrointestinal tract, lung and kidney, consisting of families and subfamilies of enzymes that are classified based on their amino acid sequence identities or similarities

It is particularly known for its relationship with the mitochondria , which are the powerhouses of the cell

10.1038/s41598-017-18828-3 274 TapW

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