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Plasma levels decline with age, which is part of why it became a research target for skin, hair, and wound healing

Tyagi et al., 2025), with probiotic and prebiotic supplementation showing anxiolytic effects in randomized controlled trials via MGBA modulation (Johnstone et al., 2021

Additionally, they point out that hyperhomocysteinemia remains an independent risk factor for thrombosis and stroke after adjustment for established risk factors