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In del[13q]CLL cells, the microRNA (miR) cluster miR-15a/miR-16-1 is deleted, leading to the loss of its tumor suppression function and overexpression of the antiapoptotic proteins B-cell lymphoma-2 (BCL-2) and myeloid cell leukemia-1 (MCL-1)

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Similarly, maternal exposure to inflammatory insults during pregnancy leads to elevated IL-6 levels in the systemic circulation, which induces IL-6R expression in fetal intestinal epithelial stem cells, this inflammatory imprint persists into adulthood, conferring increased resistance to intestinal infections in the offspring ( in vivo models

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Randomized trial of longer-term therapy for symptoms attributed to Lyme disease