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Dysregulation of the mitochondrial ACE2/MrgE/NO axis may have a significant effect on the neurodegenerative processes of dopaminergic neurons, where mitochondrial dysfunction and oxidative stress may have a substantial impact [76]

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Similar to the early production of other viral vectors [26], a scale-out approach was employed with dozens of 10-layer cell stacks and several rounds of ultracentrifugation over multiple days

Indirect immunofluorescence assay IFA was used to locate the position of SmGSTs