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108 In a second clinical study that examined 14 female subjects aged 5368 years who were amenorrheic for 110 years (mean interval, 5 years) that applied a MEP night cream (at 2%) for a total of 20 weeks displayed improvements in: a) skin texture (53%), b) keratoses (21%), and c) skin laxity (15%)

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The approval was based on a three-arm, parallel Phase I study that compared the pharmacokinetics, safety and immunogenicity of Tofidence to reference tocilizumab in healthy volunteers

Role of HIF-1 and HIF-2 in osteoarthritis