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pylori (e.g., lipopolysaccharides) activate the hosts innate immune system through pattern recognition receptors such as TLR2 and TLR4, while its virulence factors (e.g., VacA and CagA) disrupt epithelial cell integrity, induce apoptosis, and trigger inflammatory responses

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10.1111/bph.14487 19 AnH.-J.LeeW.-R.KimK.-H.KimJ.-Y.LeeS.-J.HanS.-M.et al (2014)

Pilozzi A, Carro C, Huang X (2021) Roles of -endorphin in stress, behavior, neuroinflammation, and brain energy metabolism