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Description

28 Chronically increased glutamine concentrations cause swelling of the glial cells resulting in so-called Alzheimer II type degeneration of astroglias.40, 41 Glial dysfunction contributes to the development of HE.40, 42 During hyperammonemia, the reserve capacity of the astrocytic glutamine synthetase is exceeded, and ammonia can enter the neurons

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For example, in the mouse testis, CYP51A1 expression is primarily regulated by the cAMP-responsive element modulator tau (CREMtau), which drives a germ cell-specific increase in CYP51A1 mRNA levels during spermatogenesis

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