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Oxidative stress damages DNA by producing peroxynitrite (ONOO ) from the reaction of superoxide anions and nitric oxide 14 and correlates with increased airway epithelial cell apoptosis, pro-inflammatory signaling and DNA oxidation 15

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Some evidence indicates that smoking influences the secretory function of Sertoli and Leydig cells in the testis, thereby causing the impaired sperm quality seen in smokers

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