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Brain metastasis of breast cancer can be located in the parenchymal brain (around four-fifths) or in leptomeningeal region (109)

It also increases fibroblast proliferation and collagen synthesis through the FAK-paxillin and GHR pathways

A central regulator of this process is peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), which promotes mitochondrial biogenesis and reduces inflammatory signaling

Offers neuroprotective & gut-brain axis support

For patients losing significant weight on compounded semaglutide or tirzepatide, topical GHK-Cu is sometimes used to support skin elasticity, though specific evidence in this population is limited