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Although loss of GOT1, the cytosolic aspartate aminotransferase, kills leukaemia cells upon ETC inhibition (Birsoy et al, 2015), pancreatic ductal adenocarcinoma (PDAC) cells driven by mutant K-Ras rely on both GOT2, for aspartate production, and GOT1, to convert this aspartate into oxaloacetate

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The SLC22 transporter family: A paradigm for the impact of drug transporters on metabolic pathways, Signaling, and disease

(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear