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this model is static PES improves separation but remains a single perturbation snapshot MEA captures correlates of state transitions, not full continuous dynamics This paper shows local cortical dynamics only (not whole-brain physiology) so results are: developmental-stage dependent model-specific (2D organoid in vivo brain) perturbation-dependent Why fully dynamic modeling is nearly impossible

Saliva collection for the assessment of cortisol concentration was performed at the morning (SLC MN ), afternoon (SLC AN ) and late night (SLC LN )

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