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doi: 10.3389/fendo.2023.1134208 8

Among them, persulfidation of a single cysteine in the Kir 6.1 subunits of vascular ATP-sensitive K + channel increases the activity, causing endothelial and smooth muscle cell hyperpolarization and vasorelaxation ( 2 S/HS levels have been related to the severity of Covid-19 disease through the persulfidation and activation of ATP-sensitive channels of leukocytes, which is leading to novel therapeutic interventions ( + channels, cysteine persulfidation causes inactivation

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By binding copper with an affinity similar to albumins transport site, GHK can shuttle copper to cells and influence local copper availability