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Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (82470841 to M.L.), Natural Science Foundation of Xiamen City, China (3502Z20227162 to M.L.) and Natural Science Foundation of Fujian Province, China (2023I0002 to M.L.)

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No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration)

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