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Notably, herein, we found that NACET maintained its capability to protect cells against oxidative stress even when pretreatment was followed by extensive washing, suggesting that NACET increases the internal defense mechanisms of RPE cells to cope with oxidative stress

These highly oxidizing radicals participate in the propagation of lipid peroxidation chain reactions, leading to a decrease in membrane fluidity

doi: 10.1038/s41598-025-18624-4 63 GanesanMWangWMathewsSMakarovENew-AaronMDagurRSet al

Because the skin's natural turnover process takes about 30 days, it takes time for the internal changes in melanin production to appear on the surface

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