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10.1038/s41598-017-16637-2 Sci

It is particularly relevant in experimental models examining peptide structure-function relationships

Its unique mechanism has made it one of the most extensively studied peptides for exploring the biological processes associated with cellular aging and long-term tissue maintenance

Supporting may be a dramatic decrease of glutathione levels in the rat brain after a paracetamol oral overdose (3.0 g/kg) (4) and brain tissue susceptibility to oxidative stress (high content of peroxidizable unsaturated fatty acids, high oxygen consumption per unit weight, but poorly developed antioxidative defense mechanisms) (5)

It is modeled after a protective protein fragment associated with gastric juice and has become a widely studied compound in preclinical research