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Impact of ATXN3 Misfolding on the Subcellular Compartments: Mitochondria and ER Wild-type and mutant ATXN3 proteins have also been identified in the mitochondrial protein fraction of cells [138, 139], suggesting that mitochondrial function may be impaired as a result of ATXN3 misfolding and aggregation

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25,26 MTX325: From Bench to Bedside In late 2023, the UK-based biotech company Mission Therapeutics (Mission) published a pivotal preclinical study using a mouse model of PD that conveyed the translational capabilities of MTX325