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An extensive nave dosing study with brensocatib at different dosing levels, frequencies, and durations was conducted in rodent models to determine its pharmacokinetic (PK) profile and its pharmacodynamic (PD) effects on NSPs

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IL-8 has been shown to act on mucin post-translationally through increasing the levels of RNA-binding proteins to improve stability of the mucin transcripts ( MUC5B and MUC5AC gene expression in primary tracheal epithelial cells (Chen et al., 2003), and IL-17A caused an increase of MUC5AC in primary human bronchial epithelial cells through the NF-B enhancer of MUC5AC gene transcription (Fujisawa et al., 2011

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