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In addition to being an iron-requiring hemoprotein at its catalytic center, iron levels in the macrophage have been shown to control the transcriptional expression of the enzyme, and NO, in turn, modulates the expression of genes related to iron metabolism by promoting increased binding of IRP to IRE motifs (101103)

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214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function

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[DOI] [PubMed] [Google Scholar] 174.Dragicevic N., Smith A., Lin X., Yuan F., Copes N., Delic V., et al