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In Alzheimer disease specifically, BDNF deficits are most pronounced in the hippocampus, entorhinal cortex, and prefrontal cortex, the regions earliest and hardest hit by the disease

These efforts are part of Novo Nordisk's unprecedented investment in research and development to maintain its competitive edge

Falla, T

Oxidative DNA damage results in mutations that generate dysfunctional protein gene products and altered replication and transcription of crucial genes ( Oxidative stress-induced lipid peroxidation Lipid peroxidation occurs primarily via peroxidation of unsaturated fatty acids, although saturated fatty acids and membrane cholesterol can also undergo peroxidation