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Interestingly, metformin treatment blunted this increase in mitochondria (Fig

C/VEH, n = 7) or CBD (H/CBD, n = 8

doi: 10.3389/fimmu.2026.1726566 Received 16 October 2025 Revised 27 February 2026 Accepted 09 March 2026 Published 30 March 2026 Volume 17 - 2026 Edited by Christian David Sadik, University of Lbeck, Germany Reviewed by Zhaoqi Zhang, Chinese Academy of Sciences (CAS), China Yihua Fan, Hospital of Chengdu University of Traditional Chinese Medicine, China Updates Copyright 2026 Chen, Cheng, Li and Zhao

sCT when bound to AMYRs induce a CT-like receptor conformation 15 , while P32Y substitutions of CT analogues are also detrimental to affinity and potency at AMYRs 18,19

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