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Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)

1989 Jun;86(12):46959

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Similarly, in melanoma, the overexpression of a protein called UT-B was shown to increase NO levels, leading to mitochondrial depolarization, a spike in ROS, and reduced cell viability