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These data suggest that both the inhibition of mTOR pathway and the activation of FoxO1 pathway both depend on ECM1-LRP1 interaction, ultimately preventing HSC activation and reducing liver fibrosis in mice

What we do know from the switching protocols published by various clinical practices is that starting low and titrating up works better than trying to jump to an "equivalent" dose

However, the study was small, lacked a placebo control and evaluated biomarkers rather than long-term clinical outcomes